Process prioritization enables organizations to ensure that the projects and initiatives they invest into are aligned with their organization goals. This enables a value-driven focus of digital transformation and business continuity initiatives, based on the strategy of the organization. The paper describes how the business strategy can be operationalized to serve as the foundation to identify processes with a high impact on the strategy. High impact, low maturity processes are best targets for digital transformation and business continuity initiatives. Projects focused on those deliver most value to the organization. The continuous adjustment of priorities and related project portfolios requires an appropriate digital tool support to enable “what-if”analysis. The prioritization approach is illustrated through case examples.